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Peak Appearance, Calif., Apr 27, 2012/PRNewswire/- VIVUS, Inc. NASDAQ: VVUS nowadays announced that the Aliment and Drug Government FDA has approved STENDRA avanafil tablets for the treatment of erectile dysfunction ED, marking the aboriginal fresh prescription agent approved in almost a decade for the case that afflicts as abounding as 30 million men in the

Patients and treating physicians abide to report meaningful dissatisfaction with contemporary treatments of ED, said Peter Tam, president, VIVUS VVUS. We accept that the PDE5 selectivity and absorption profileof STENDRA accomplish it an valuable fresh treatment choice for abounding men with erectile dysfunction.

Added than 1, 200 men with ED participated in clinical studies evaluating the efficacy and safety of STENDRA. STENDRA at all doses tested 50mg, 100mg and 200mg met all important efficacy endpoints. Meaningful improvement in erectile service was observed for all doses in STENDRA-treated patients compared to placebo.

It is recommendedthat STENDRA should be taken around 30 minutes before sexual life. STENDRA should not be taken added than once per time. For added advice approximately STENDRA, please appointment

STENDRA is the aboriginal of a fresh time of PDE5 inhibitors, and the approval marks an agitative fresh milestone for the millions of men suffering from erectile dysfunction who are in charge of a fresh treatment choice, said Dr. Wayne Hellstrom, Professor of Urology and Chief of Andrology man infertility and sexual dysfunction at Tulane University College of Medicine in Fresh Orleans.

ED affects an estimated 52 percent of men between the ages of 40 and 70. Prevalence increases with time and can be caused by a array of factors, including medications anti-hypertensives, histamine receptor antagonists; lifestyle tobacco, alcohol employ; diseases diabetes, cardiovascular conditions, prostate cancer; and spinal cord injuries. Left untreated, ED can negatively force relationships and self-esteem, causing feelings of embarrassment and guilt. But, approximately half of men life treated with currently available PDE5 inhibitors are dissatisfied with treatment. The marketplace possibility for ED medical treatments continues to abound, with worldwide sales of PDE5 inhibitors exceeding 5 billion in 2011.

VIVUS is currently in analysis with possible partners to commercialize STENDRA in the United States and in its territories in remainder of the apple.

STENDRA avanafil is licensed from Mitsubishi Tanabe Pharma Company. VIVUS has process and commercial rights to STENDRA for the treatment of sexual dysfunction worldwide with the exception of sure Asian Peacemaking Rim countries. In South Korea, STENDRA is approved and is marketed by JW Pharma under the brand designation Zepeed.

STENDRA avanafil is prescribed to treat erectile dysfunction ED.

Accomplish not booty STENDRA provided you booty nitrates, generally prescribed for chest affliction, as this may account a sudden, unsafe drop in blood force.

Altercate your common health status with your healthcare provider to arrange that you are healthy enough to engage in sexual life. Provided you familiarity chest affliction, nausea, or any other discomforts during female, seek prompt medical advice.

STENDRA may act on the action other medicines assignment. Impart your healthcare provider provided you booty any of the next; medicines called HIV protease inhibitors, such as ritonavir Norvir, indinavir Crixivan, saquinavir Fortavase or Invirase or atazanir Reyataz; some types of spoken antifungal medicines, such as ketoconazole Nizoral, and itraconozale Sporonox; or some types of antibiotics, such as clarithromycin Biaxin, telithromycin Ketek, or erythromycin.

In the unusual fact of an erection fast added than 4 hours, seek prompt medical advice to avoid long-term injury.

In unusual instances, men captivating PDE5 inhibitors spoken erectile dysfunction medicines, including STENDRA reported a sudden cut or loss of eyes. It is not imaginable to actuate if these events are related directly to these medicines or to other factors. Provided you familiarity sudden cut or loss of eyes, point captivating PDE5 inhibitors, including STENDRA, and phone a doctor appropriate out.

Sudden cut or loss of hearing has been seldom reported in bodies captivating PDE5 inhibitors, including STENDRA. It is not imaginable to actuate if these events are related directly to the PDE5 inhibitors or to other factors. Provided you familiarity sudden cut or loss of hearing, point captivating STENDRA and contact a doctor appropriate out. Provided you accept prostate problems or aerial blood force for which you booty medicines called alpha blockers or other anti-hypertensives, your doctor may commence you on a lower dose of STENDRA.

Drinking also even alcohol when captivating STENDRA may escort to headache, dizziness, and lower blood force.

STENDRA in combination with other treatments for ED is not recommended.

STENDRA does not protect against sexually transmitted diseases, including HIV.

The most general side thing of STENDRA are headache, flushing, runny nose and congestion.

Please look complete patient prescribing advice for STENDRA 50 mg, 100 mg, 200 mg tablets.

You are encouraged to report abrogating side thing of prescription drugs to the FDA. Appointment /medwatch, or phone 1-800- FDA - 1088.

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Filagra pinkIt is not imaginable to actuate if these events are related directly to these medicines or to other factors. Provided you familiarity sudden cut or loss of eyes, point captivating PDE5 inhibitors, including STENDRA, and phone a doctor appropriate out.

Sudden cut or loss of hearing has been seldom reported in bodies captivating PDE5 inhibitors, including STENDRA. It is not imaginable to actuate if these events are related directly to the PDE5 inhibitors or to other factors. Provided you familiarity sudden cut or loss of hearing, point captivating STENDRA and contact a doctor appropriate out. Provided you accept prostate problems or aerial blood force for which you booty medicines called alpha blockers or other anti-hypertensives, your doctor may commence you on a lower dose of STENDRA.

Drinking also even alcohol when captivating STENDRA may escort to headache, dizziness, and lower blood force.

STENDRA in combination with other treatments for ED is not recommended.

STENDRA does not protect against sexually transmitted diseases, including HIV.

The most general side thing of STENDRA are headache, flushing, runny nose and congestion.

Please look complete patient prescribing advice for STENDRA 50 mg, 100 mg, 200 mg tablets.

You are encouraged to report abrogating side thing of prescription drugs to the FDA. Appointment /medwatch, or phone 1-800-FDA-1088.

VIVUS is a biopharmaceutical corporation developing therapies to domicile fatness, sleep apnea, diabetes and man sexual health. The corporation s escort investigational product in clinical process, Qnexa, has completed page 3 clinical trials for the treatment of fatness and is currently life considered for approval by US and EU regulators. VIVUS received a All Response Mail, or CRL, to the initial Qnexa NDA on Oct 28, 2010. Vivus resubmitted the Qnexa NDA in Oct 2011, which has a FDA activity time of July 17, 2012. On Feb 22, 2012, in a 20-to-2 ballot, the Aliment and Drug Government Endocrinologic and Metabolic Drugs Advisory Comittee recommended that Qnexa be granted marketing approval by the FDA for the treatment of fatness in adults. Qnexa is again in page 2 clinical process for the treatment of type 2 diabetes and obstructive sleep apnea. For added advice approximately the corporation, please appointment

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Peak Appearance, Calif., Apr 27, 2012/PRNewswire/- VIVUS, Inc. VVUS nowadays announced that the Aliment and Drug Government FDA has approved STENDRA avanafil tablets for the treatment of erectile dysfunction ED, marking the aboriginal fresh prescription agent approved in almost a decade for the case that afflicts as abounding as 30 million men in the

Patients and treating physicians abide to report meaningful dissatisfaction with contemporary treatments of ED, said Peter Tam, president, VIVUS. We accept that the PDE5 selectivity and absorption profile of STENDRA accomplish it an valuable fresh treatment choice for abounding men with erectile dysfunction.

Added than 1, 200 men with ED participated in clinical studies evaluating the efficacy and safety of STENDRA. STENDRA at all doses tested 50mg, 100mg and 200mg met all important efficacy endpoints. Meaningful improvement in erectile service was observed for all doses in STENDRA-treated patients compared to placebo.

It is recommended that STENDRA should be taken around 30 minutes before sexual life. STENDRA should not be taken added than once per time. For added advice approximately STENDRA, please appointment

STENDRA is the aboriginal of a fresh time of PDE5 inhibitors, and the approval marks an agitative fresh milestone for the millions of men suffering from erectile dysfunction who are in charge of a fresh treatment choice, said Dr. Wayne Hellstrom, Professor of Urology and Chief of Andrology man infertility and sexual dysfunction at Tulane University College of Medicine in Fresh Orleans.

ED affects an estimated 52 percent of men between the ages of 40 and 70. Prevalence increases with time and can be caused by a array of factors, including medications anti-hypertensives, histamine receptor antagonists; lifestyle tobacco, alcohol employ; diseases diabetes, cardiovascular conditions, prostate cancer; and spinal cord injuries. Left untreated, ED can negatively force relationships and self-esteem, causing feelings of embarrassment and guilt. But, approximately half of men life treated with currently available PDE5 inhibitors are dissatisfied with treatment. The marketplace possibility for ED medical treatments continues to abound, with worldwide sales of PDE5 inhibitors exceeding 5 billion in 2011.

VIVUS is currently in analysis with possible partners to commercialize STENDRA in the United States and in its territories in remainder of the apple.

STENDRA avanafil is licensed from Mitsubishi Tanabe Pharma Company. VIVUS has process and commercial rights to STENDRA for the treatment of sexual dysfunction worldwide with the exception of sure Asian Peacemaking Rim countries. In South Korea, STENDRA is approved and is marketed by JW Pharma under the brand designation Zepeed.

STENDRA avanafil is prescribed to treat erectile dysfunction ED.

Accomplish not booty STENDRA provided you booty nitrates, generally prescribed for chest affliction, as this may account a sudden, unsafe drop in blood force.

Altercate your common health status with your healthcare provider to arrange that you are healthy enough to engage in sexual life. Provided you familiarity chest affliction, nausea, or any other discomforts during female, seek prompt medical advice.

STENDRA may act on the action other medicines assignment. Impart your healthcare provider provided you booty any of the next; medicines called HIV protease inhibitors, such as ritonavir Norvir, indinavir Crixivan, saquinavir Fortavase or Invirase or atazanir Reyataz; some types of spoken antifungal medicines, such as ketoconazole Nizoral, and itraconozale Sporonox; or some types of antibiotics, such as clarithromycin Biaxin, telithromycin Ketek, or erythromycin.

In the unusual fact of an erection fast added than 4 hours, seek prompt medical advice to avoid long-term injury.

In unusual instances, men captivating PDE5 inhibitors spoken erectile dysfunction medicines, including STENDRA reported a sudden cut or loss of eyes. It is not imaginable to actuate if these events are related directly to these medicines or to other factors. Provided you familiarity sudden cut or loss of eyes, point captivating PDE5 inhibitors, including STENDRA, and phone a doctor appropriate out.

Sudden cut or loss of hearing has been seldom reported in bodies captivating PDE5 inhibitors, including STENDRA. It is not imaginable to actuate if these events are related directly to the PDE5 inhibitors or to other factors. Provided you familiarity sudden cut or loss of hearing, point captivating STENDRA and contact a doctor appropriate out. Provided you accept prostate problems or aerial blood force for which you booty medicines called alpha blockers or other anti-hypertensives, your doctor may commence you on a lower dose of STENDRA.

Drinking also even alcohol when captivating STENDRA may escort to headache, dizziness, and lower blood force.

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Avanafil for the treatment of erectile dysfunction: a multicenter, randomized, double-blind read in men with diabetes mellitus.

Selectivity of Avanafil, a PDE5 Inhibitor for the Treatment of Erectile Dysfunction: Implications for Clinical Safety and Improved Tolerability.

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Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction.

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FDA has approved STENDRA avanafil tablets for the treatment of erectile dysfunction ED, marking the aboriginal fresh prescription agent approved in almost a decade for the case that afflicts as abounding as 30 million men in the

Patients and treating physicians abide to report meaningful dissatisfaction with contemporary treatments of ED, said

We accept that the PDE5 selectivity and absorption profileof STENDRA accomplish it an valuable fresh treatment choice for abounding men with erectile dysfunction.

Added than 1, 200 men with ED participated in clinical studies evaluating the efficacy and safety of STENDRA. STENDRA at all doses tested 50mg, 100mg and 200mg met all important efficacy endpoints. Meaningful improvement in erectile service was observed for all doses in STENDRA - treated patients compared to placebo.

It is recommendedthat STENDRA should be taken around 30 minutes before sexual life. STENDRA should not be taken added than once per time. For added advice approximately STENDRA, please appointment

STENDRA is the aboriginal of a fresh time of PDE5 inhibitors, and the approval marks an agitative fresh milestone for the millions of men suffering from erectile dysfunction who are in charge of a fresh treatment choice, said Dr.

Professor of Urology and Chief of Andrology man infertility and sexual dysfunction at

ED affects an estimated 52 percent of men between the ages of 40 and 70. Prevalence increases with time and can be caused by a array of factors, including medications anti-hypertensives, histamine receptor antagonists; lifestyle tobacco, alcohol employ; diseases diabetes, cardiovascular conditions, prostate cancer; and spinal cord injuries. Left untreated, ED can negatively force relationships and self-esteem, causing feelings of embarrassment and guilt. But, approximately half of men life treated with currently available PDE5 inhibitors are dissatisfied with treatment. The marketplace possibility for ED medical treatments continues to abound, with worldwide sales of PDE5 inhibitors exceeding

STENDRA avanafil is licensed from Mitsubishi Tanabe Pharma Company.

has process and commercial rights to STENDRA for the treatment of sexual dysfunction worldwide with the exception of sure Asian Peacemaking Rim countries. In South Korea, STENDRA is approved and is marketed by JW Pharma under the brand designation Zepeed.

STENDRA avanafil is prescribed to treat erectile dysfunction ED.

Accomplish not booty STENDRA provided you booty nitrates, generally prescribed for chest affliction, as this may account a sudden, unsafe drop in blood force.

Altercate your common health status with your healthcare provider to arrange that you are healthy enough to engage in sexual life. Provided you familiarity chest affliction, nausea, or any other discomforts during female, seek prompt medical advice.

STENDRA may act on the action other medicines assignment. Impart your healthcare provider provided you booty any of the next; medicines called HIV protease inhibitors, such as ritonavir Norvir, indinavir Crixivan, saquinavir Fortavase or Invirase or atazanir Reyataz; some types of spoken antifungal medicines, such as ketoconazole Nizoral, and itraconozale Sporonox; or some types of antibiotics, such as clarithromycin Biaxin, telithromycin Ketek, or erythromycin.

In the unusual fact of an erection fast added than 4 hours, seek prompt medical advice to avoid long-term injury.

In unusual instances, men captivating PDE5 inhibitors spoken erectile dysfunction medicines, including STENDRA reported a sudden cut or loss of eyes. It is not imaginable to actuate if these events are related directly to these medicines or to other factors. Provided you familiarity sudden cut or loss of eyes, point captivating PDE5 inhibitors, including STENDRA, and phone a doctor appropriate out.

Sudden cut or loss of hearing has been seldom reported in bodies captivating PDE5 inhibitors, including STENDRA. It is not imaginable to actuate if these events are related directly to the PDE5 inhibitors or to other factors. Provided you familiarity sudden cut or loss of hearing, point captivating STENDRA and contact a doctor appropriate out. Provided you accept prostate problems or aerial blood force for which you booty medicines called alpha blockers or other anti-hypertensives, your doctor may commence you on a lower dose of STENDRA.

Drinking also even alcohol when captivating STENDRA may escort to headache, dizziness, and lower blood force.

STENDRA in combination with other treatments for ED is not recommended.

STENDRA does not protect against sexually transmitted diseases, including HIV.

The most general side thing of STENDRA are headache, flushing, runny nose and congestion.

Please look complete patient prescribing advice for STENDRA 50 mg, 100 mg, 200 mg tablets.

is a biopharmaceutical corporation developing therapies to domicile fatness, sleep apnea, diabetes and man sexual health. The companys escort investigational product in clinical process, Qnexa, has completed page 3 clinical trials for the treatment of fatness and is currently life considered for approval by US and EU regulators.

received a All Response Mail, or CRL, to the initial Qnexa NDA on

in a 20-to-2 ballot, the Aliment and Drug Government Endocrinologic and

for the treatment of fatness in adults. Qnexa is again in page 2 clinical process for the treatment of type 2 diabetes and obstructive sleep apnea. For added advice approximately the corporation, please appointment

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Eriacta ukThis was a single-center, double-blind, randomized, 3-way crossover test of healthy males from 30 to 60 age of time. Subjects were divided among 5 test groups with the test accumulation life bent by the age space between treatment with test drug and glyceryl trinitrate government. Subjects were assigned to test groups sequentially and hemodynamic results from the preceding accumulation were reviewed for austere adverse events SAEs before the abutting accumulation received treatment. Each man was dosed with all 3 read drugs STENDRA 200 mg, sildenafil citrate 100 mg, and placebo in haphazard course. Subjects were administered a unmarried dose of 0.4 mg sublingual nitroglycerin NTG at pre-specified age points, next their dose of test drug 0.5, 1, 4, 8 or 12 hours. Overall, 14 15% subjects treated with placebo and 28 28% subjects treated with avanafil, had clinically meaningful decreases in standing SBP, defined as better than or equal to 30 mmHg cut in SBP, after glyceryl trinitrate government. Beggarly maximum decreases are shown in Table 4.

Table 4: Beggarly Maximum Decreases from Baseline in Sitting and Standing Systolic Blood Force/Diastolic Blood Force mmHg next Placebo or 200 mg STENDRA with 0.4 mg sublingual nitroglycerin

Love other PDE5 inhibitors, STENDRA government with nitrates is contraindicated. In a patient who has taken STENDRA, where nitrate government is deemed medically needed in a activity threatening bearings, at least 12 hours should elapse after the at the end dose of STENDRA before nitrate government is considered. In such circumstances, nitrates should even alone be administered under fast medical supervision with take hemodynamic monitoring look Contraindications 4.1.

A single-center, randomized, double-blinded, placebo-controlled, two-period crossover test was conducted to enquire the possible interplay of STENDRA with alpha-blocker agents in healthy man subjects which consisted of two cohorts:

Cohort A N24: Subjects received spoken doses of doxazosin once daily in the morning at 1 mg for 1 time Time 1, 2 mg for 2 days Days 2 3, 4 mg for 4 days Days 4 7, and 8 mg for 11 days Days 8 18. On Days 15 and 18, the subjects again received a unmarried spoken dose of either 200 mg STENDRA or placebo, according to the treatment randomization law. The STENDRA or placebo doses were administered 1.3 hours after the doxazosin government on Days 15 and 18. The co-administration was designed so that doxazosin T max 2 hours and STENDRA T max 0.7 hours would grasp their top plasma concentrations at the identical age.

Cohort B N24: Subjects received 0.4 mg daily spoken doses of tamsulosin in the morning for 11 consecutive days Days 1 11. On Days 8 and 11, the subjects again received a unmarried spoken dose of either 200 mg STENDRA or placebo, according to the treatment randomization law. The STENDRA or placebo doses were administered 3.3 hours after the tamsulosin government on Days 8 and 11. The co-administration was designed so that tamsulosin T max 4 hours and STENDRA T max 0.7 hours would grasp their top plasma concentrations at the identical age.

Supine and sitting BP and pulse percentage measurements were recorded before and after STENDRA or placebo dosing.

A complete of seven subjects in Cohort A doxazosin experienced potentially clinically valuable real values or changes from baseline in standing SBP or DBP. Three subjects experienced standing SBP values less than 85 mmHg. One man experienced a cut from baseline in standing SBP better than 30 mmHg next STENDRA. Two subjects experienced standing DBP values less than 45 mmHg next STENDRA. Four subjects experienced decreases from baseline in standing DBP better than 20 mmHg next STENDRA. One man experienced such decreases next placebo. There were no severe adverse events related to hypotension reported during the test. There were no cases of syncope.

A complete of five subjects in Cohort B tamsulosin experienced potentially clinically valuable real values or changes from baseline in standing SBP or DBP. Two subjects experienced standing SBP values less than 85 mmHg next STENDRA. One man experienced a cut from baseline in standing SBP better than 30 mmHg next STENDRA. Two subjects experienced standing DBP values less than 45 mmHg next STENDRA. Four subjects experienced decreases from baseline in standing DBP better than 20 mmHg next STENDRA; one man experienced such decreases next placebo. There were no severe adverse events related to hypotension reported during the test. There were no cases of syncope.

Table 5 presents the placebo-subtracted beggarly maximum decreases from baseline 95% CI in systolic blood force results for the 24 subjects who received STENDRA 200 mg and matching placebo.

Blood force thing standing SBP in normotensive men on steady dose doxazosin 8 mg next government of STENDRA 200 mg or placebo, are shown in Figure 2. Blood force thing standing SBP in normotensive men on steady dose tamsulosin 0.4 mg next government of STENDRA 200 mg or placebo are shown in Figure 3.

A test was conducted to evaluate the interplay of enalapril 20 mg daily and STENDRA 200 mg. Unmarried doses of 200 mg STENDRA co-administered with enalapril caused a beggarly maximum cut in supine systolic/diastolic blood force of 1.8/3.5 mmHg compared to placebo, accompanied by a beggarly maximum access in pulse percentage of 1.0 bpm.

A test was conducted to evaluate the interplay of amlodipine 5 mg daily and STENDRA 200 mg. Unmarried doses of 200 mg STENDRA co-administered with amlodipine caused a beggarly maximum cut in supine systolic blood force of 1.2 mmHg compared to placebo, accompanied by a beggarly maximum access in pulse percentage of 1.0 bpm; the beggarly maximum cut in diastolic blood force was less than that observed in the placebo accumulation. There was no aftereffect of STENDRA on amlodipine plasma concentrations. Concomitant amlodipine was associated with 22% and 70% increases in avanafil C max and AUC, respectively.

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Peak Appearance, Calif., Apr 27, 2012/PRNewswire/- VIVUS, Inc. NASDAQ: VVUS nowadays announced that the Aliment and Drug Government FDA has approved STENDRA avanafil tablets for the treatment of erectile dysfunction ED, marking the aboriginal fresh prescription agent approved in almost a decade for the case that afflicts as abounding as 30 million men in the

Patients and treating physicians abide to report meaningful dissatisfaction with contemporary treatments of ED, said Peter Tam, president, VIVUS. We accept that the PDE5 selectivity and absorption profilePof STENDRA accomplish it an valuable fresh treatment choice for abounding men with erectile dysfunction.

Added than 1, 200 men with ED participated in clinical studies evaluating the efficacy and safety of STENDRA. STENDRA at all doses tested 50mg, 100mg and 200mg met all important efficacy endpoints. Meaningful improvement in erectile service was observed for all doses in STENDRA - treated patients compared to placebo.

It is recommendedPthat STENDRA should be taken around 30 minutes before sexual life. STENDRA should not be taken added than once per time. P For added advice approximately STENDRA, please appointment

STENDRA is the aboriginal of a fresh time of PDE5 inhibitors, and the approval marks an agitative fresh milestone for the millions of men suffering from erectile dysfunction who are in charge of a fresh treatment choice, said Dr. Wayne Hellstrom, Professor of Urology and Chief of Andrology man infertility and sexual dysfunction at Tulane University College of Medicine in Fresh Orleans.

ED affects an estimated 52 percent of men between the ages of 40 and 70. Prevalence increases with time and can be caused by a array of factors, including medications anti-hypertensives, histamine receptor antagonists; lifestyle tobacco, alcohol employ; diseases diabetes, cardiovascular conditions, prostate cancer; and spinal cord injuries. Left untreated, ED can negatively force relationships and self-esteem, causing feelings of embarrassment and guilt. But, approximately half of men life treated with currently available PDE5 inhibitors are dissatisfied with treatment. The marketplace possibility for ED medical treatments continues to abound, with worldwide sales of PDE5 inhibitors exceeding 5 billion in 2011.P

VIVUS is currently in analysis with possible partners to commercialize STENDRA in the United States and in its territories in remainder of the apple.

STENDRA avanafil is licensed from Mitsubishi Tanabe Pharma Company. VIVUS has process and commercial rights to STENDRA for the treatment of sexual dysfunction worldwide with the exception of sure Asian Peacemaking Rim South Korea, STENDRA is approved and is marketed by JW Pharma under the brand designation Zepeed. P

STENDRA - avanafil is prescribed to treat erectile dysfunction ED.

Accomplish not booty STENDRA provided you booty nitrates, generally prescribed for chest affliction, as this may account a sudden, unsafe drop in blood force.

Altercate your common health status with your healthcare provider to arrange that you are healthy enough to engage in sexual life. Provided you familiarity chest affliction, nausea, or any other discomforts during female, seek prompt medical advice.

STENDRA may act on the action other medicines assignment. P Impart your healthcare provider provided you booty any of the next; medicines called HIV protease inhibitors, such as ritonavir Norvir, indinavir Crixivan, saquinavir Fortavase or Invirase or atazanir Reyataz; some types of spoken antifungal medicines, such as ketoconazole Nizoral, and itraconozale Sporonox; or some types of antibiotics, such as clarithromycin Biaxin, telithromycin Ketek, or erythromycin.

In the unusual fact of an erection fast added than 4 hours, seek prompt medical advice to avoid long-term injury.

In unusual instances, men captivating PDE5 inhibitors spoken erectile dysfunction medicines, including STENDRA reported a sudden cut or loss of eyes. It is not imaginable to actuate if these events are related directly to these medicines or to other factors. Provided you familiarity sudden cut or loss of eyes, point captivating PDE5 inhibitors, including STENDRA, and phone a doctor appropriate out.

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super Filagra kaufenErectile dysfunction refers to a man‚s inability to accomplish a penile erection, or to preserve one. Erectile dysfunction is again accepted as man impotence.

Avana is a medication that is taken, when needed, 30 minutes before starting sexual life. Doctors are advised to prescribe the lowest dose at which help is if for the patients.

The studies again show Avanafil clears the object added quickly than the other ED drugs in the identical group, the phosphodiesterase type 5 PDE5 inhibitors, according to information submitted to the FDA by Vivus Inc who produces Stendra or Avanafil.

In a Page II read, Avanafil worked too as Viagra while producing less low blood force in cardiac patients who booty nitroglycerin. In the two Page III trials that compared Avanafil with a placebo, there were no reports of dejected eyes or prolonged, painful erections priapism, which are few side thing associated with Viagra. In unusual cases, men captivating any of the PDE5 drugshave reported sudden decreases in hearing or loss of hearing Avanafil Side EffectsGeneric Stendra Side Thing

Stendra is faster than all ED - Stendra Generic Avanafil is the new quickly acting erectile dysfunction medication that is again accepted as Avanfil. Erectile dysfunction is whereby a male has problem in achieving or maintaining a penile erection. This case persists in absolutely an estimable population of men. It works by blocking PDE 5 enzymes and incrementing your blood flow towards the penis hence manufacture an erection imaginable. One takes this tablet orally.

Stendra Generic Vs. Stendra Brand - Generic medicines are typically seen as a less able counterpart of an established and recognizable brand, rather than a added economical idea with aloof as abounding benefits show for the recipient of the medication. The stigma of not having a brand designation and spending added in finances to afford the identical medication as it has the added famend designation should never be a agency when it comes to the medical needs of those that buy them. The actuality of the affair is, generic drugs and medicines are aloof as able as their expensive counterparts and should be seen as a just, provided not the aboriginal, choice when it comes down to it.

Stendra Dosage - Stendra prescription is in baby dosage, which ensures it extends to the welfare of the patients. This dosage may be 100 mg however may vary between 200 mg and 50 mg depending on the doctor‚s recommendations. One takes it 30 minutes before involving in any sexual life either before a meal or after. Notice that in some instances it works in approximately 15 Minutes. One again needs to booty it alone once in a time. It is advisable to store it at a space temperature.

Is Stendra Generic Avanafil The Top ED - As a fresh drug in the marketplace, Stendra Generic Avanafil has absolutely some superiority on the other existing drugs that treat erectile dysfunction. It works faster and the blood stream expels it even faster thereby having minimal side thing. Moreover, it is again added efficacious to attaining an erection. With the affectation of these qualities, it is accordingly a even safer choice also.

Stendra Side Thing - The notable side thing tend to be headaches, flushes and nasal congestion that may comprehend running or stuffy nose. Provided you familiarity these thing, it is advisable you consult your doctor. You should again notice to notify the doctor of any medications you might be captivating to arrange the drug works efficiently. You again charge to avoid alcohol while on this medication as it brings approximately dizziness.

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Advice on this point is if for informational purposes and is not meant to substitute for the help if by your own physician or other medical able. You should not employ the advice contained herein for diagnosing or treating a health botheration or disease, or prescribing any medication. You should glance at carefully all product packaging. Provided you accept or suspect that you accept a medical botheration, now contact your health affliction provider.

VIVUS Inc. NASDAQ: VVUS said the European Medicines Agency EMA has general a Marketing Authorization Use MAA for the discussion of avanafil, its investigational drug for the treatment of erectile dysfunction ED, and itssharesgained 3.14% in premarket trading.

The corporation said EMA submission follows the acknowledged completion of an long page 3 programme for avanafil, which included over 1, 350 patients.

The MAA includes results from three placebo-controlled, randomized, double-blind, multicenter studies: REVIVE, which included 646 men from the common population with ED, REVIVE-Diabetes, which included 390 diabetics, and REVIVE-RP, which included 298 men next fundamental prostatectomy.

Again included are the results from the year-long safety read, TA-314, which included 712 continuation patients from the REVIVE and REVIVE-Diabetes studies.

Avanafil is an spoken investigational drug life developed for the treatment of erectile dysfunction. Avanafil is a highly selective phosphodiesterase type 5 PDE5 inhibitor licensed from Mitsubishi Tanabe Pharma Corp.

VIVUS owns worldwide process and commercial rights to avanafil for the treatment of sexual dysfunction, with the exception of sure Asian Peacemaking Rim countries. In South Korea, avanafil is approved and is marketed by JW Pharma under the brand designation Zepeed. VIVUS has submitted an NDA for avanafil, a PDE5 inhibitor life studied for the treatment of erectile dysfunction, with an FDA activity time of Apr 29.

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tadalista20The doses of 50mg and 100mg Viagra enable a male 2.1 times added possible to accept an erection. Approximately 75% of the men captivating Viagra said that their erectile service significantly improved. Approximately 80% of the men captivating Stendra reported the improved erections.

The moment position to assess is the accomplishment in intercourse. Approximately 90% of the men captivating Viagra can attain an erection hard enough for sexual fact at a 40% accomplishment percentage. Approximately 40% of men familiarity a accomplishment percentage of added than 60% with Viagra. Stendra 25 mg provides acknowledged erections in 45 64% of cases, the dose of 100 mg helps 46- 74% of men, and the dose of 200 mg improves erectile service from 48% to 77% cases.

Viagra and Stendra are both PDE5-inhibitors with agnate mechanism of activity, contraindications and adverse thing. The most general side thing reported virtually at the identical rates for both medications are: headaches, flushing of the face or neck, belly agitated and nasal congestion. Even such unusual however disagreeable side aftereffect of Viagra as dejected eyes reported by approximately 3% of patients has not even been observed for Stendra. Too, there were no such austere adverse thing as hearing loss and confusion with Stendra. Doctors even warn patients to be attentive to their case while using any PDE 5 inhibitor including Stendra.

Patients with passion diseases are exceptionally attracted with Stendra due to its aerial safety. The service of Stendra over Viagra is in the opportunity of Stendra life used in cardiac patients much in those who booty nitroglycerin. Stendra in combination with nitrates is even less possible than Viagra to account dangerously low blood force.

Both Viagra and Stendra are used by mouth when needed, even Stendra has the supplementary help of employ: it provides an erection even faster than Viagra. With Stendra men can accept an erection within 15 minutes, which gives added spontaneity in sexual life.

Sometimes medications are prescribed for other medical purposes for which they are not directly indicated. Accomplish not employ Stendra containing Avanafil for case for which it is not intended to be used. Accomplish not accord Stendra to other bodies much provided they accept the identical symptoms as you. Stendra is a prescription medication, before using it, you should consult your doctor.

Booty Stendra as your doctor orders you to booty it. Chase your doctors recommendations on the dose and age of captivating the medication. Never exceed your dose without aboriginal consulting your doctor. Your doctor may chicken feed your dose of the drug in conformity with your response to the therapy.

Stendra is taken when needed 30 minutes before sexual life. Stendra is to be taken no added than once in a time 24 hours. Stendra initial dose should be the lowest that works for you. The dose of the medication may depend on the other conditions you may accept.

Stendra should not be used with alcohol, street drugs or nitrates. Also even alcohol may access your chance of side thing. Buzz your doctor what size of alcohol you may drink.

Before using this medication you should appointment your doctor to assess your case. Your doctor will assess the severity of your case, actuate its account and adjust appropriate tests. Your doctor offers you altered treatment methods for ED, even most doctors are inclined to prescribe most able and protected treatment method - the usage of PDE5 inhibitors including a fresh medication Stendra avanafil.

Before prescribing you Stendra your doctor will buzz you provided you accept other health conditions. These disorders may contradict with the usage of Stendra or appropriate dose adjustments may be needed. Impart your doctor provided you accept any of the next:

Stendra is a prescription medication with sure contraindications and side thing. It may be harmful for sure groups of patients, so before using it buzz your doctor provided you can safely booty this drug.

Women and children should not booty this drug. Men younger than 18 age of aged should not employ this medication. Men who accomplish not familiarity ED botheration should not booty this drug.

Stendra s safety and efficacy were estimated in 3 leading double-blind, placebo-controlled clinical trials. 1, 267 patients were administered Stendra for up to 12 weeks at doses of 50 mg, 100 mg or 200 mg, or a placebo when needed approximately 30 minutes before sexual life.

Patients were to all appropriate diaries to evaluate erectile service and acknowledged intercourse. The results of the studies demonstrated that males receiving Stendra had meaningful improvements in erectile service and common fulfilment in sexual intercourse for all three doses of Stendra in comparison with placebo.

The Stendra s safety was evaluated in a accumulation of patients from two of the preceding studies. They participated in an supplementary 40 weeks of Stendra treatment. Males received 100 mg of Stendra, and then the dose was increased to 200 mg or lowered to 50 mg depending on their alone response to therapy. The findings were that the adverse reactions commonly occurring in analysis participants using Stendra did not worsen over age.

The Aliment and Drug Government approved a fresh medication for the treatment of erectile dysfunction ED in men on Apr 27, 2012. Stendra is brand designation of the medication. The generic designation is avanafil which is a PDE5 inhibitor used to treat erectile dysfunction. Stendra is marketed by Peak Appearance, California-based VIVUS Inc.

ED is a too general case in men of altered ages. Men who familiarity ED accept problem in getting and/or care an erection during sexual intercourse. Older men are added affected by this case due to the actuality that with time men buy abounding diseases which can contribute to the process of ED. Too, abounding experts accede the ageing action to be one of the leading factors causing ED in men.

This fresh approved spoken medication gives added chances for the patient with ED to select between available treatment options and acquisition the most able proper medical treatment.

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Buy Avigra 5, 2011/PRNewswire/- VIVUS, Inc. NASDAQ: VVUS nowadays announced that multiple abstracts were presented over the weekend at the 2011 European Country of Sexual Medicine ESSM Affair in Milan, Italy. The ESSM is the largest company of medical professionals specializing in sexual dysfunction and treatment in Europe. The particular abstracts that were presented on Dec 3rd, 2011 comprehend: A moderated poster presentation

Peak Appearance, Calif., November. 14, 2011/PRNewswire/- VIVUS, Inc. NASDAQ: VVUS nowadays announced that fresh analyzes from TA-314, a page 3 long-term safety and efficacy read of the investigational drug avanafil for the treatment of erectile dysfunction ED, was presented over the weekend at the 2011 Sexual Medicine Country of North America SMSNA Affair in Las Vegas, NV. Andy R. McCullough, MD, Professor of Surgery/Urology at Albany Medical School, presented the discussion of

Peak Appearance, Calif., November. 10, 2011/PRNewswire/- Highlights from Avanafil Process Programme Comprehend: Early start of activity observed in placebo-controlled trialsComparative in-vitro selectivity of avanafil, sildenafil, vardenafil and tadalafilSafety and efficacy in post-prostatectomy populationVIVUS, Inc. NASDAQ: VVUS nowadays announced that multiple abstracts will be presented at the Sexual Medicine Country of North America SMSNA on Nov 12, 2011 in Las Vegas, NV. The SMSNA

Peak Appearance, Calif., November. 3, 2011/PRNewswire/- VIVUS, Inc. NASDAQ: VVUS nowadays announced that Timothy Morris, chief financial officer, will show an overview of the corporation at the Credit Suisse 2011 Healthcare Convention. The VIVUS presentation will booty put at the Arizona Biltmore Hotel in Phoenix, AZ on Thursday, Nov 10, 2011 at 9:30 MST. A alive webcast and 30-day archive of the presentation will be available at

Peak Appearance, Calif., October. 14, 2011/PRNewswire/- VIVUS, Inc. NASDAQ: VVUS nowadays announced that Timothy Morris, chief financial officer, will show an overview of the corporation at the 2011 BioCentury NewsMakers in the Biotech Industry Convention. The VIVUS presentation will booty put at the Millennium Broadway Hotel in Fresh York, NY on Friday, Oct 21, 2011 at 10:00 ET. A alive webcast and 30-day archive of the presentation will be available at Approximately

Reuters is not amenable for the content in this press release.

Peak Appearance, Calif., Apr 27, 2012/PRNewswire/- VIVUS, Inc. NASDAQ: VVUS nowadays announced that the Aliment and Drug Government FDA has approved STENDRA avanafil tablets for the treatment of erectile dysfunction ED, marking the aboriginal fresh prescription agent approved in almost a decade for the case that afflicts as abounding as 30 million men in the

Patients and treating physicians abide to report meaningful dissatisfaction with contemporary treatments of ED, said Peter Tam, president, VIVUS. We accept that the PDE5 selectivity and absorption profileof STENDRA accomplish it an valuable fresh treatment choice for abounding men with erectile dysfunction.

Added than 1, 200 men with ED participated in clinical studies evaluating the efficacy and safety of STENDRA. STENDRA at all doses tested 50mg, 100mg and 200mg met all important efficacy endpoints. Meaningful improvement in erectile service was observed for all doses in STENDRA - treated patients compared to placebo.

It is recommendedthat STENDRA should be taken around 30 minutes before sexual life. STENDRA should not be taken added than once per time. For added advice approximately STENDRA, please appointment

STENDRA is the aboriginal of a fresh time of PDE5 inhibitors, and the approval marks an agitative fresh milestone for the millions of men suffering from erectile dysfunction who are in charge of a fresh treatment choice, said Dr. Wayne Hellstrom, Professor of Urology and Chief of Andrology man infertility and sexual dysfunction at Tulane University College of Medicine in Fresh Orleans.

ED affects an estimated 52 percent of men between the ages of 40 and 70. Prevalence increases with time and can be caused by a array of factors, including medications anti-hypertensives, histamine receptor antagonists; lifestyle tobacco, alcohol employ; diseases diabetes, cardiovascular conditions, prostate cancer; and spinal cord injuries. Left untreated, ED can negatively force relationships and self-esteem, causing feelings of embarrassment and guilt. But, approximately half of men life treated with currently available PDE5 inhibitors are dissatisfied with treatment. The marketplace possibility for ED medical treatments continues to abound, with worldwide sales of PDE5 inhibitors exceeding 5 billion in 2011.

VIVUS is currently in analysis with possible partners to commercialize STENDRA in the United States and in its territories in remainder of the apple.

STENDRA avanafil is licensed from Mitsubishi Tanabe Pharma Company. VIVUS has process and commercial rights to STENDRA for the treatment of sexual dysfunction worldwide with the exception of sure Asian Peacemaking Rim countries. In South Korea, STENDRA is approved and is marketed by JW Pharma under the brand designation Zepeed.

STENDRA avanafil is prescribed to treat erectile dysfunction ED.

Accomplish not booty STENDRA provided you booty nitrates, generally prescribed for chest affliction, as this may account a sudden, unsafe drop in blood force.

Altercate your common health status with your healthcare provider to arrange that you are healthy enough to engage in sexual life. Provided you familiarity chest affliction, nausea, or any other discomforts during female, seek prompt medical advice.

STENDRA may act on the action other medicines assignment. Impart your healthcare provider provided you booty any of the next; medicines called HIV protease inhibitors, such as ritonavir Norvir, indinavir Crixivan, saquinavir Fortavase or Invirase or atazanir Reyataz; some types of spoken antifungal medicines, such as ketoconazole Nizoral, and itraconozale Sporonox; or some types of antibiotics, such as clarithromycin Biaxin, telithromycin Ketek, or erythromycin.

In the unusual fact of an erection fast added than 4 hours, seek prompt medical advice to avoid long-term injury.

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Vidalista reviewThe trials enrolled subjects who self administered Stendra 50 mg, 100 mg, or 200 mg 30 minutes prior to initiating sexual life. Subjects could ask an adaption in treatment dosage based on alone response. The 3 important outcome measures were the erectile service realm of the International Index of Erectile Service IIEF and Questions 2 and 3 from Sexual Encounter Profile September. Stendra demonstrated statistically meaningful improvement from baseline in all three dose arms against the placebo. A subset of patients from 2 of these trials were enrolled into an open-label space test to assess Stendra in ED patients with type 1 or type 2 diabetes mellitus in a randomized, double-blind, paralell, placebo-controlled constant dose test of 3 months in life. Stendra or placebo was administered in doses of 100 mg or 200 mg. Subjects in the treatment arms demonstrated statistically meaningful improvement from baseline against the placebo upon test based on the IIEF and September measures.

Adverse reactions associated with the employ of Stendra may comprehend, however are not local to, the next:

Stendra avanafil phosphodiesterase 5 PDE5 inhibitor. PDE5 is amenable for the degradation of cGMP, which produces smooth muscle relaxation in the corpus cavernosum and allows influx of blood. The physiologic mechanism of erection of the penis involves release of nitric oxide NO in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation in the corpus cavernosum and allowing influx of blood. Avanafil has no administer relaxant aftereffect on remoted human corpus cavernosum, however enhances the aftereffect of NO by inhibiting PDE5. As sexual stimulation is required to start the community release of nitric oxide, the inhibition of PDE5 has no aftereffect in the absence of sexual stimulation.

For supplementary advice regarding Stendra or erectile dysfunction, please appointment the Vivus interlacing sheet.

The Stendra drug advice shown above is licensed from Thomson CenterWatch. The advice if here is for common educational purposes alone and does not make medical or pharmaceutical help which should be sought from able medical and pharmaceutical advisers.

MediLexicon International Ltd 2004-2012 All rights reserved.

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Branch of Urology, Chonbuk State University Medical College, and School for Medical Sciences, Chonbuk State University, and Test School of Clinical Medicine of Chonbuk State University and Chonbuk State University Hospital and CTC for Medical Device of Chonbuk State University Hospital, Jeonju Branch of Urology, School of Medicine, Catholic University Branch of Urology, School of Medicine, Hallym University Branch of Urology, School of Medicine, Korea University Branch of Urology, School of Medicine, Sungkyunkwan University Branch of Urology, School of Medicine, Seoul State University Branch of Urology, School of Medicine, Ulsan University Branch of Urology, School of Medicine, Ihwa University, Seoul Branch of Urology, School of Medicine, Pusan State University Branch of Urology, School of Medicine, Inje University, Busan Branch of Urology, School of Medicine, Youngnam University, Daegu Branch of Urology, School of Medicine, Inha University, Incheon Branch of Urology, School of Medicine, Kyungsang State University, Jinju Branch of Urology, School of Medicine, Chonnam State University, Gwangju, Korea.

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